Safety and effectiveness for other pediatric uses have not been established. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. The stability of esomeprazole magnesium is function of it rapidly degrades in acidic media, but it has acceptable stability under alkaline conditions. To view our editorial policy, content sources and attributions please click here. This product information is intended for US nexium sans medecin Health Care professionals only. Concomitant administration of clarithromycin with cisapride, pimozide, astemizole, terfenadine, ergotamine, or dihydroergotamine is contraindicated see prescribing information for clarithromycin. CYP 2C19 isoenzyme exhibits polymorphism in the metabolism of esomeprazole, since some of Caucasians and 15 to 20 of Asians lack CYP 2C19 and are termed Poor Metabolizers.